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홍차넷
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질문
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- 질문 게시판입니다.
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전체기타게임진로연애가정/육아체육/스포츠교육의료/건강철학/종교IT/컴퓨터여행과학문화/예술법률홍차넷경제
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Warning: Use of undefined constant x - assumed 'x' (this will throw an Error in a future version of PHP) in /home/redtea/html/pb/view.php on line 398
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| Date |
Warning: Use of undefined constant reg_date - assumed 'reg_date' (this will throw an Error in a future version of PHP) in /home/redtea/html/a_skin/bbsd/view.php on line 53 20/03/06 11:37:55 Warning: Use of undefined constant mod_date - assumed 'mod_date' (this will throw an Error in a future version of PHP) in /home/redtea/html/a_skin/bbsd/view.php on line 56 |
| Name | [익명] |
| Subject | 코로나 진단 키트가 믿을만 할까요? |
|
제가 검사했던 사람 히스토리 들어보면 확진자와 밀접 접촉했음에도 모두 음성이 나왔구요. 제가 있는 지역에도 중국인이 대량으로 다녀갔음에도 생각보다 양성 나온경우가 많지 않기두 하구요. 타원에서는 여러번 음성 나오다 나중에 양성으로 나오는 경우도 있고, 완치 판정 받았는데 나중에 다시 양성으로 나오는 경우도 있는걸 보면,, low titer의 경우 찾아내지 못하는게 아닌가 하는 의구심이 듭니다. 실제로 이것밖에 안되는 걸까? 더 많은게 아닐까? 이런 전염력이 높은 질환의 경우 false positive 보다는 false negative가 더 문제가 될텐데.. 질문란에 올렸지만, 사실은 넋두리 입니다. Warning: Use of undefined constant no - assumed 'no' (this will throw an Error in a future version of PHP) in /home/redtea/html/a_skin/bbsd/view.php on line 133 Warning: Use of undefined constant no - assumed 'no' (this will throw an Error in a future version of PHP) in /home/redtea/html/a_skin/bbsd/view.php on line 146 Warning: Use of undefined constant vote - assumed 'vote' (this will throw an Error in a future version of PHP) in /home/redtea/html/a_skin/bbsd/view.php on line 161 0 |
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80067 class="iamcmt" style="display:none;"> Warning: Use of undefined constant no - assumed 'no' (this will throw an Error in a future version of PHP) in /home/redtea/html/a_skin/bbsd/view_comment.php on line 66
80067 class='vcm '>
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80067'> Zel
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20/03/06 12:01
80067>삭제 주소복사
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아마 질문하시는 분이 가장 잘 아실텐데.. 크게 검사채취의 문제, RT-PCR의 문제, 바이러스의 문제 등이 있겠고요.. 검사채취에서 위음성을 만드는 다는건 잘 알려져 있어서 적절한 채취가 가장 중요한 것으로 알려져 있습니다. RT-PCR 자체는 결국 이게 증폭시키고 35사이클 이내에서 나와야 양성인데, viral load자체가 적어서 위음성이 나오는 경우도 있고 지금 너무 다양한 키트를 사용하고 있기 때문에 QC가 얼마만큼 잘 되었는 지 솔직히 미지수입니다. 병원에서도 임상의사들은 대략 심지어 정량적인 데이터도 자신병원이나 타병원에 대한 adjustment등을 고려하거든요 (우리병원 특정 암표지자는 ... 더 보기
아마 질문하시는 분이 가장 잘 아실텐데.. 크게 검사채취의 문제, RT-PCR의 문제, 바이러스의 문제 등이 있겠고요.. 검사채취에서 위음성을 만드는 다는건 잘 알려져 있어서 적절한 채취가 가장 중요한 것으로 알려져 있습니다. RT-PCR 자체는 결국 이게 증폭시키고 35사이클 이내에서 나와야 양성인데, viral load자체가 적어서 위음성이 나오는 경우도 있고 지금 너무 다양한 키트를 사용하고 있기 때문에 QC가 얼마만큼 잘 되었는 지 솔직히 미지수입니다. 병원에서도 임상의사들은 대략 심지어 정량적인 데이터도 자신병원이나 타병원에 대한 adjustment등을 고려하거든요 (우리병원 특정 암표지자는 항상 좀 적게 나오는 경향이 있다) 뭐 이런게 있는데 이와같이 dichotomous 한 결과를 보이지만 사실상 연속선상의 결과라.. 그리고 마지막으론 코로나 바이러스 자체가 워낙 나왔다 없어졌다 하는 소위 dynamic conversion이 심한 것으로 알려져 있어서 어려운 것 같습니다.
개인적으론 한 차례에 걸친 rRT-PCR로 확진자에서 제외한다는건 상당히 성급하지만, 그렇게 믿고 싶고 믿어야 하는 상황이 이를 더 조장하지 않나 싶습니다. 개개인은 진료지침대로 할 수 밖에 없고, 말이 좋아 위음성 100%이지 이를 달성하기 위해선 또 threshold가 너무 치우쳐져서 위양성을 더 만드는건 모든 검사법의 한계라 어쩔 수 없을 겁니다. 현실적으로도 어렵고
일반적 rRT-PCR에 대해서는 cdc 문서를 참조하십시오. https://www.cdc.gov/coronavirus/2019-ncov/lab/rt-pcr-detection-instructions.html
개인적으론 한 차례에 걸친 rRT-PCR로 확진자에서 제외한다는건 상당히 성급하지만, 그렇게 믿고 싶고 믿어야 하는 상황이 이를 더 조장하지 않나 싶습니다. 개개인은 진료지침대로 할 수 밖에 없고, 말이 좋아 위음성 100%이지 이를 달성하기 위해선 또 threshold가 너무 치우쳐져서 위양성을 더 만드는건 모든 검사법의 한계라 어쩔 수 없을 겁니다. 현실적으로도 어렵고
일반적 rRT-PCR에 대해서는 cdc 문서를 참조하십시오. https://www.cdc.gov/coronavirus/2019-ncov/lab/rt-pcr-detection-instructions.html
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